2022
Title: Pharmacogenomics of SGLT2 inhibitors – investigating the role of empagliflozin in epigenetic modification of non-coding RNA – sirtuin – Sodium-glucose cotransporter-2 axis after myocardial infarction
PI: Anna Nowak, MD
Funding: Preludium 21, National Science Centre (grant number 2022/45/N/NZ7/02461)
Project duration: : 2022-2025
Amount: EUR 45,000
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Department of Cardiology, Medical University of Vienna, Vienna, Austria
- Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Austria
Title: Application of metabolomics, proteomics, and bioinformatic tools to determine pathophysiological changes due to endurance training in ultramarathon runners
PI: Zofia Wicik, PhD, MSc
Funding: Miniatura, National Science Centre (grant number 2022/06/X/NZ7/01071)
Project duration: : 2022-2023
Amount: EUR 11,500
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Department of Regenerative Medicine, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
Title: Understanding contribution of platelets and platelet function in epigenetics of Wilson’s Disease
PI: Ceren Eyileten Postula, DVM, PhD, MSc
Funding: Sonata 17 Grant, National Science Centre (grant number 2021/43/D/NZ2/02380)
Project duration: : 2022-2025
Amount: EUR 385,000
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Centre of New Technologies, University of Warsaw
- Institute of Psychiatry and Neurology in Warsaw
2021
Title: Application of next generation sequencing and computational tools to determine non-coding RNAs expression in endurance athletes
PI: Piotr Szwed, MD
Funding: Preludium 20 Grant, National Science Centre (grant number 2021/41/N/NZ2/02783)
Project duration: : 2022-2025
Amount: EUR 45,000
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Sportslab – Sports Diagnostics Center
- Centre of New Technologies, University of Warsaw
2020
Title: EMpagliflozin and daPAgliflozin in patients hospiTalized for acute decompensated Heart failure (EMPATHY trial).
Funding: Medical Research Agency grant (grant number 2019/ABM/01/00037)
Project duration: : 2020-2026
Amount: EUR 6,948,000
Project summary: National, multicenter, randomized, double-blind, parallel-group, stratified by SGLT-2 inhibitor type, placebo-controlled trial, – a Phase III study. The primary objective is to investigate the impact of SGLT-2 inhibitors (Empagliflozin and Dapagliflozin) on primary and secondary clinical endpoints in patients with acute/decompensated HF with and without type 2 diabetes mellitus within 78 weeks after the event. Non-commercial, randomized, double blind clinical trial.
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Bielanski Father Jerzy Popiełuszko Hospital, Independent Public Heath Care Facility in Warsaw
- Regional Multispecialist Hospital in Kielce
- Medical University of Łódź
- Medical University of Gdańsk
- Independent Public Specialized Health Care Facility, St. John Paul II Zachodni Hospital in Grodzisk Mazowiecki
- Nicolaus Copernicus University in Toruń
- University Hospital of the Medical University in Poznań
- Department of Interventional Cardiology, Institute of Cardiology, Collegium Medicum, Jagiellonian University Specialized John Paul II Hospital in Kraków
- Medical University of Wrocław
- Medical University of Białystok
- Medical University of Silesia
- Medical University of Vienna
- Medical University of Graz
- University Hospital Center of Medical University of Warsaw
Title: Platelet extracellular vesicles as biomarkers of subclinical leaflet stenosis after transcatheter aortic valve implantation.
Funding: Club 30 of the Polish Cardiac Society
Project duration: 2020 – 2022 (24 months)
Amount: EUR 12,000
Project summary: Prospective, observational, multicentre study to develop a novel biomarker for early identification of patients with subclinical leaflet stenosis after transcatheter aortic valve implantation based on platelet extracellular vesicles.
Collaborators:
- 1st Chair and Department of Cardiology, Medical University of Warsaw
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Department of Cardiology, Hospital Nowa Sól, Zielona Góra University, Zielona Góra, Poland
- 1st Department of Cardiology, Medical University of Gdańsk, Gdańsk, Poland
- Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland
- Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands
Title: Platelet extracellular vesicles as biomarkers of developing coronary thrombosis.
Funding: Club 30 of the Polish Cardiac Society
Project duration: 2020 – 2021 (6 months)
Amount: EUR 10,000
Project summary: Prospective, observational, multicentre study to develop a novel biomarker for early identification of patients before the onset of an occlusive coronary thrombus and irreversible damage of the cardiac muscle based on platelet extracellular vesicles.
Collaborators:
- 1st Chair and Department of Cardiology, Medical University of Warsaw;
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland;
- Department of Cardiology, Hospital Nowa Sól, Zielona Góra University, Zielona Góra, Poland;
- Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands;
- Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
2019
Title: Evaluation of prognostic value of platelet-derived extracellular microvesicles and microRNA in patients witch ischemic stroke of undetermined source- ESUS.
Funding: Polish National Science Centre research grant (grant number 2018/31/B/NZ7/01137).
Project duration: 2019-2023
Amount: EUR 418,000
Project Summary: The main objective of this study is to characterize platelet-derived extracellular vesicles (PEV) and peripheral blood miRNAs (both PEVs-related and circulating profiles) in patients with embolic stroke of undetermined source (ESUS) in order to analyze their diagnostic and prognostic utility
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Department of Medical and Surgical Sciences, Magna Graecia University,
University of Catanzaro, Italy - Laboratory of Experimental Clinical Chemistry, and Vesicle Observation Centre, Academic Medical Centre of University of Amsterdam
- Genetic and Molecular Epidemiology Laboratory, McMaster University Hamilton, Canada, Division of Cardiology
Title: Prognostic value of platelet-derived microRNA in patients with acute coronary syndrome treated with novel P2Y12 receptor antagonists
Funding: National Science Centre
Project number: 2018/31/N/NZ7/02260
Project duration: 2019 –2022 (36 months)
Amount: EUR 50,000
Project summary: Prospective, observational, multicentre study to determine the effect of novel, potent antiplatelet drugs, ticagrelor and prasugrel on circulating platelet-derived microRNAs in relation to platelet reactivity in the acute phase of acute coronary syndrome, and to investigate whether combined evaluation of circulating platelet-derived miRNAs and platelet reactivity improves the prediction of recurrent ischaemic events over 3 years observation.
Collaborators:
- 1st Chair and Department of Cardiology, Medical University of Warsaw
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Department of Cardiology, Medical University of Vienna, Vienna, Austria
- Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands
2017
Title: Evaluation of platelet-derived extracellular vesicles and selected platelets-derived miRNAs in relation to platelet reactivity and their changes over time in patients with acute ischemic stroke.
Funding: Polish National Science Centre research grant (grant number 2017/25/N/NZ5/00545).
Project duration: 2017-2021
Amount: EUR 72,000
Summary: The main objective of this project is to study and characterize platelet extracellular vesicles and circulating platelet-derived microRNAs in relation to platelet reactivity in patients with embolic stroke with large artery atherosclerosis in the acute phase of the disease and up 30-days after events during acetylsalicylic acid (ASA) therapy.
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, University of Catanzaro, Italy
- Laboratory of Experimental Clinical Chemistry, and Vesicle Observation Centre, Academic Medical Centre of the University of Amsterdam
Title: MicroRNA analysis in type 2 diabetes patients and its potential role as a diagnostic and prognostic biomarker of platelets reactivity and cardiovascular events.
Funding: Ministry of Science and Higher Education “Diamentowy Grant” research grant (grant number 072/DIA/2017/46).
Duration: 2017-2021
Amount: EUR 72,000
Project summary: The main objective of this project is to study and characterize novel microRNAs in type 2 diabetes patients and its potential role as a diagnostic and prognostic biomarker of platelets reactivity and cardiovascular event
Collaborators:
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland
- Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, University of Catanzaro
- Department of Cardiology, Medical University of Vienna, Vienna, Austria